Propioxatins A and B, new enkephalinase B inhibitors. II. Structural elucidation.
نویسندگان
چکیده
The structures of propioxatins A (C17H29N3O6) and B (C18H31N3O6), new enkephalinase B inhibitors produced by Kitasatosporia setae SANK 60684, were determined. Both propioxatins consist of N-acyl-L-prolyl-L-valine. N-Acyl moieties of propioxatins A and B were alpha-propyl and alpha-isobutyl succinic acid beta-hydroxamic acid, respectively.
منابع مشابه
Propioxatins A and B, new enkephalinase B inhibitors. I. Taxonomy, fermentation, isolation and biological properties.
A soil isolate of actinomycete, strain SANK 60684, was found to produce new enkephalinase B inhibitors, propioxatins A and B. The presence of both LL- and meso-2,6-diaminopimelic acid, glycine and galactose in the cell wall assigned this strain to genus Kitasatosporia. From the morphological, cultural and physiological characteristics, this strain was determined to be Kitasatosporia setae. The ...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 39 10 شماره
صفحات -
تاریخ انتشار 1986